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Silver‐Catalyzed Cross‐Coupling of Propargylic Alcohols with Isocyanides: An Atom‐Economical Synthesis of 2,3‐Allenamides
Author(s) -
Liu Jianquan,
Liu Zhenhua,
Wu Nannan,
Liao Peiqiu,
Bi Xihe
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201304255
Subject(s) - catalysis , coupling (piping) , atom (system on chip) , chemistry , combinatorial chemistry , organic chemistry , materials science , computer science , parallel computing , metallurgy
Cross‐coupling reactions between propargylic alcohols and isocyanides, by means of silver catalysis, have been described. This new reaction is both atom and step efficient and is applicable to a broad scope of substrates, allowing the synthesis of a range of synthetically valuable 2,3‐allenamides in moderate to excellent yields.