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Pd–Carbene Migratory Insertion: Application to the Synthesis of Trifluoromethylated Alkenes and Dienes
Author(s) -
Wang Xi,
Xu Yan,
Deng Yifan,
Zhou Yujing,
Feng Jiajie,
Ji Guojing,
Zhang Yan,
Wang Jianbo
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201304143
Subject(s) - carbene , migratory insertion , diazo , chemistry , halide , combinatorial chemistry , medicinal chemistry , catalysis , organic chemistry
Pd‐catalyzed cross‐coupling of halides with CF 3 ‐substituted diazo compounds or N ‐tosylhydrazones has been explored for the synthesis of CF 3 ‐substituted alkenes and 1,3‐butadienes. Pd–carbene migratory insertion plays the key role in these transformations.