Premium
Unprecedented High‐Nuclear Transition‐Metal‐Cluster‐Substituted Heteropolyoxoniobates: Synthesis by {V 8 } Ring Insertion into the POM Matrix and Antitumor Activities
Author(s) -
Shen JianQiang,
Wu Qiong,
Zhang Ying,
Zhang ZhiMing,
Li YangGuang,
Lu Ying,
Wang EnBo
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201303995
Subject(s) - thermogravimetric analysis , vanadium , vanadate , chemistry , transition metal , crystallography , cluster (spacecraft) , metal , ring (chemistry) , zinc , stereochemistry , nuclear chemistry , inorganic chemistry , catalysis , organic chemistry , computer science , programming language
Reactions of hexaniobate with vanadate in the presence of Ni 2+ , Zn 2+ , or Cu 2+ have furnished three high‐nuclear vanadium cluster‐substituted heteropolyoxoniobates (HPNs): {Ni(en) 3 } 5 H{V V Nb 8 V IV 8 O 44 } ⋅ 9 H 2 O ( 1 ), (H 2 en)Na 2 [{Zn(en) 2 (Hen)}{Zn(en) 2 (H 2 O)} 2 {PNb 8 V IV 8 O 44 }] ⋅ 11 H 2 O ( 2 ), and Na{Cu(en) 2 } 3 {[Cu(en) 2 ] 2 [PNb 8 V IV 8 O 44 ]} ⋅ 11 H 2 O ( 3 ) (en=1,2‐diaminoethane). Their structures have been determined and characterized by single‐crystal X‐ray diffraction analysis, thermogravimetric analysis (TGA), and elemental analysis. Structural analysis has revealed that compounds 1 – 3 contain similar {V 8 }‐substituted [X V Nb 8 V IV 8 O 44 ] 11− (X=P, V) clusters, obtained by inserting a {V 8 } ring into tetravacant HPN [XNb 8 O 36 ] 27− . To the best of our knowledge, compounds 1 – 3 represent the first high‐nuclear vanadium cluster‐substituted HPNs, and compound 1 is the largest vanadoniobate cluster yet obtained in HPN chemistry. Nickel and zinc cations have been introduced into HPNs for the first time, which might promise a more diverse set of structures in this family. Antitumor studies have indicated that compounds 1 and 2 exhibit high activity against human gastric cancer SGC‐7901 cells, SC‐1680 cells, and MG‐63 cells.