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Hydrogen‐Bonding in Aminocatalysis: From Proline and Beyond
Author(s) -
Albrecht Łukasz,
Jiang Hao,
Jørgensen Karl Anker
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201303982
Subject(s) - hydrogen bond , proline , hydrogen , chemistry , materials science , nanotechnology , computer science , molecule , organic chemistry , amino acid , biochemistry
This Concept article summarizes recent progress in the field of hydrogen‐bonding aminocatalysis using proline‐derived systems. The aminocatalysts available in the literature are categorized by the incorporated hydrogen‐bonding scaffold and its mode of recognition. Both mono‐ and double‐hydrogen‐bonding motifs are discussed and examples of their application in asymmetric synthesis are given.