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A General Method for N‐Methylation of Amines and Nitro Compounds with Dimethylsulfoxide
Author(s) -
Jiang Xue,
Wang Chao,
Wei Yawen,
Xue Dong,
Liu Zhaotie,
Xiao Jianliang
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201303802
Subject(s) - nitro , formic acid , methylation , amine gas treating , chemistry , catalysis , transformation (genetics) , organic chemistry , medicinal chemistry , combinatorial chemistry , biochemistry , gene , alkyl
DMSO methylates a broad range of amines in the presence of formic acid, providing a novel, green and practical method for amine methylation. The protocol also allows the one‐pot transformation of aromatic nitro compounds into dimethylated amines in the presence of a simple iron catalyst.
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