Premium
Potassium Isopropoxide: For Sulfination It is the Only Base You Need!
Author(s) -
Sayah Mahmoud,
Organ Michael G.
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201303756
Subject(s) - toluene , catalysis , potassium , chemistry , base (topology) , combinatorial chemistry , medicinal chemistry , organic chemistry , mathematics , mathematical analysis
PEPPSI max : KO i Pr has been identified as the key ingredient for Pd‐catalyzed sulfination (see scheme). Potassium is essential to keep the thiol concentration low, and isopropoxide is necessary for precatalyst activation and to break up Pd‐sufide‐based resting states. Together with the reactive Pd‐PEPPSI‐IPent Cl o ‐picoline catalyst, this system couples profoundly deactivated partners at RT that other catalysts cannot accomplish in refluxing toluene.