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How Water Interacts with Halogenated Anesthetics: The Rotational Spectrum of Isoflurane–Water
Author(s) -
Gou Qian,
Feng Gang,
Evangelisti Luca,
VallejoLópez Montserrat,
Spada Lorenzo,
Lesarri Alberto,
Cocinero Emilio J.,
Caminati Walther
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201303724
Subject(s) - isotopologue , conformational isomerism , hyperfine structure , isoflurane , rotational spectroscopy , quadrupole , chemistry , hydrogen bond , molecule , spectral line , microwave , anesthetic , nuclear magnetic resonance , atomic physics , anesthesia , organic chemistry , physics , medicine , quantum mechanics , astronomy
The rotational spectra of several isotopologues of the 1:1 complex between the inhaled anesthetic isoflurane and water have been recorded and analyzed by using Fourier transform microwave spectroscopy. The rotational spectrum showed a single rotamer, corresponding to the configuration in which the most stable conformer of isolated isoflurane is linked to the water molecule through an almost linear CH⋅⋅⋅O weak hydrogen bond. All transitions display a hyperfine structure due to the 35 Cl (or 37 Cl) nuclear quadrupole effects.