Copper‐Catalyzed Trifluoromethylation and Cyclization of Aromatic‐Sulfonyl‐Group‐Tethered Alkenes for the Construction of 1,2‐Benzothiazinane Dioxide Type Compounds | Zendy

Dong Xiang | Zendy; Sang Rui | Zendy; Wang Qiang | Zendy; Tang XiangYing | Zendy; Shi Min | Zendy

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Copper‐Catalyzed Trifluoromethylation and Cyclization of Aromatic‐Sulfonyl‐Group‐Tethered Alkenes for the Construction of 1,2‐Benzothiazinane Dioxide Type Compounds

Author(s) -

Dong Xiang,

Sang Rui,

Wang Qiang,

Tang XiangYing,

Shi Min

Publication year - 2013

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201303623

Subject(s) - trifluoromethylation , annulation , chemistry , tandem , combinatorial chemistry , catalysis , sulfonyl , functional group , computer science , organic chemistry , engineering , alkyl , trifluoromethyl , polymer , aerospace engineering

A multi‐talented system : An efficient copper‐catalyzed tandem trifluoromethylation/annulation of an electron‐deficient aromatic ring has been developed. This method provides a powerful and straightforward way to synthesize trifluoromethylated 1,2‐benzothiazinane dioxides under mild conditions (see scheme). The mechanism was investigated by a series of kinetic experiments and isotopic labeling studies.

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