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Enantioselective Copper(I/II)‐Catalyzed Conjugate Addition of Nitro Esters to β,γ‐Unsaturated α‐Ketoesters
Author(s) -
Zhang Sheng,
Xu Kun,
Guo Fengfeng,
Hu Yanbin,
Zha Zhenggen,
Wang Zhiyong
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201303512
Subject(s) - enantioselective synthesis , conjugate , copper , catalysis , nitro , michael reaction , chemistry , organic chemistry , addition reaction , combinatorial chemistry , medicinal chemistry , mathematics , mathematical analysis , alkyl
A highly enantioselective Michael addition of nitroacetates to β,γ‐unsaturated α‐ketoesters was developed by using chiral copper catalysts. The Michael addition products can be obtained in high yields with up to 99 % ee . With these densely functionalized products, the chiral cyclic nitrones, which are important synthetic intermediates, can be obtained in one step.