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General and Practical Carboxyl‐Group‐Directed Remote CH Oxygenation Reactions of Arenes
Author(s) -
Wang Yang,
Gulevich Anton V.,
Gevorgyan Vladimir
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201303511
Subject(s) - oxygenation , combinatorial chemistry , chemistry , computer science , catalysis , information retrieval , organic chemistry , medicine , anesthesia
Two methods for remote aromatic CH oxygenation reactions, have been developed. Method 1, the Cu‐catalyzed oxygenation reaction, is highly efficient for cyclization of electron‐neutral and electron‐rich biaryl carboxylic acids into 3,4‐benzocoumarins. Method 2, the K 2 S 2 O 8 ‐mediated oxygenation reaction, is more general and practical for cyclization of substrates with electron‐donating and ‐withdrawing groups (see scheme).