z-logo
Premium
Highly Enantioselective Hydrogenation of 1‐Alkylvinyl Benzoates: A Simple, Nonenzymatic Access to Chiral 2‐Alkanols
Author(s) -
Kleman Patryk,
GonzálezListe Pedro J.,
GarcíaGarrido Sergio E.,
Cadierno Victorio,
Pizzano Antonio
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201303500
Subject(s) - enantioselective synthesis , norbornadiene , catalysis , enol , organic chemistry , chemistry , ligand (biochemistry) , computer science , combinatorial chemistry , scope (computer science) , programming language , biochemistry , receptor
Going chiral! Highly enantioselective catalytic hydrogenations of enol esters 1 by using a Rh catalyst bearing a POP ligand are described (see scheme; NBD=norbornadiene). The catalytic system has a broad scope and allows the preparation of a wide range of chiral esters 2 bearing diverse alkyls or a benzyl group with high enantioselectivities. These esters can easily be converted in highly enantioenriched 2‐alkanols.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here