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Optimizing Divalent Inhibitors of Pseudomonas aeruginosa Lectin LecA by Using A Rigid Spacer
Author(s) -
Pertici Francesca,
de Mol Nico J.,
Kemmink Johan,
Pieters Roland J.
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201303463
Subject(s) - linker , divalent , pseudomonas aeruginosa , lectin , chemistry , combinatorial chemistry , computer science , computational biology , biochemistry , stereochemistry , biology , bacteria , organic chemistry , genetics , programming language
Rigid spacers : Optimal highly potent divalent ligands of the P. aeruginosa lectin LecA have been prepared. The ligands consist of a rigid spacer derived from glucose–triazole units (see figure). Systematic variation of the number of spacer units and the aglycon linker led to a 7500‐fold enhancement in potency.