Optimizing Divalent Inhibitors of  Pseudomonas aeruginosa  Lectin LecA by Using A Rigid Spacer | Zendy

Pertici Francesca | Zendy; de Mol Nico J. | Zendy; Kemmink Johan | Zendy; Pieters Roland J. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Optimizing Divalent Inhibitors of Pseudomonas aeruginosa Lectin LecA by Using A Rigid Spacer

Author(s) -

Pertici Francesca,

de Mol Nico J.,

Kemmink Johan,

Pieters Roland J.

Publication year - 2013

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201303463

Subject(s) - linker , divalent , pseudomonas aeruginosa , lectin , chemistry , combinatorial chemistry , computer science , computational biology , biochemistry , stereochemistry , biology , bacteria , organic chemistry , genetics , programming language

Rigid spacers : Optimal highly potent divalent ligands of the P. aeruginosa lectin LecA have been prepared. The ligands consist of a rigid spacer derived from glucose–triazole units (see figure). Systematic variation of the number of spacer units and the aglycon linker led to a 7500‐fold enhancement in potency.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research