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One‐Pot Synthesis of 3‐Alkylidenephthalides from Benzoic Acids by a Rhodium‐Catalyzed ortho ‐CH Acylation Process
Author(s) -
Danoun Grégory,
Mamone Patrizia,
Gooßen Lukas J.
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201303426
Subject(s) - acylation , rhodium , chemistry , catalysis , benzoic acid , cascade , organic chemistry , surface modification , medicinal chemistry , chromatography
CH functionalization : A [Rh(cod)Cl] 2 /CsF (cod=1,5‐cyclooctadiene) catalyst system was found to promote the straightforward synthesis of 3‐alkylidenephthalides from benzoic acids and aliphatic acids or anhydrides through a one‐pot CH acylation/acylalization/elimination cascade (see scheme).