Epimerization‐Free C‐Terminal Peptide Activation | Zendy

Popovic Stanimir | Zendy; Bieräugel Hans | Zendy; Detz Remko J. | Zendy; Kluwer Alexander M. | Zendy; Koole Jelmer A. A. | Zendy; Streefkerk Dieuwertje E. | Zendy; Hiemstra Henk | Zendy; van Maarseveen Jan H. | Zendy

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Epimerization‐Free C‐Terminal Peptide Activation

Author(s) -

Popovic Stanimir,

Bieräugel Hans,

Detz Remko J.,

Kluwer Alexander M.,

Koole Jelmer A. A.,

Streefkerk Dieuwertje E.,

Hiemstra Henk,

van Maarseveen Jan H.

Publication year - 2013

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201303347

Subject(s) - epimer , racemization , terminal (telecommunication) , peptide , chemistry , chemical ligation , computer science , ligation , native chemical ligation , combinatorial chemistry , stereochemistry , computational biology , world wide web , biochemistry , chemical synthesis , biology , computer network , microbiology and biotechnology , in vitro

Smooth operation : C‐terminal peptide activation with full stereointegrity was accomplished using a copper(II)‐mediated coupling reaction of carboxylic acids with arylboroxines (see scheme, NCL = native chemical ligation, Boc = tert ‐butoxycarbonyl). This method allows epimerization‐free activation and ligation of peptides with racemization‐prone phenylglycine at the C terminus.

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