Premium
DMSO‐Mediated Ligand Dissociation: Renaissance for Biological Activity of N ‐Heterocyclic‐[Ru(η 6 ‐arene)Cl 2 ] Drug Candidates
Author(s) -
Patra Malay,
Joshi Tanmaya,
Pierroz Vanessa,
Ingram Katrin,
Kaiser Marcel,
Ferrari Stefano,
Spingler Bernhard,
Keiser Jennifer,
Gasser Gilles
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201303341
Subject(s) - chemistry , ligand (biochemistry) , the renaissance , dissociation (chemistry) , biological activity , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , in vitro , biochemistry , receptor , art history , art
Slipped under the radar? 1 H NMR spectroscopic examination revealed that [Ru(η 6 ‐arene)Cl 2 (L)] (L= N‐ heterocyclic ligands) complexes readily undergo a ligand exchange reaction in DMSO (see scheme), a popular medium for preparing stock solutions for biological screening. It is therefore highly important for researchers to study the stability in DMSO before reporting on the biological activity of such complexes.