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A Copper(I)‐Catalyzed Three‐Component Domino Process: Assembly of Complex 1,2,3‐Triazolyl‐5‐Phosphonates from Azides, Alkynes, and H ‐Phosphates
Author(s) -
Li Lingjun,
Hao Guoliang,
Zhu Anlian,
Fan Xincui,
Zhang Guisheng,
Zhang Lihe
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201303324
Subject(s) - alkyne , phosphonate , domino , catalysis , azide , chemistry , copper , combinatorial chemistry , click chemistry , phosphate , component (thermodynamics) , cascade reaction , organic chemistry , polymer chemistry , physics , thermodynamics
Three is better than one! A new copper‐catalyzed tricomponent reaction of a terminal alkyne, organic azide, and H ‐phosphate (CuAA[P]C) leads to a structurally diverse polysubstituted 1,2,3‐triazolyl‐5‐phosphonate, which provides an efficient tool for the direct introduction of phosphonic acid groups by a “click reaction” (see scheme).