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Total Synthesis of (18 S )‐ and (18 R )‐Homolargazole by Rhodium‐Catalyzed Hydrocarboxylation
Author(s) -
Schotes Christoph,
Ostrovskyi Dmytro,
Senger Johanna,
Schmidtkunz Karin,
Jung Manfred,
Breit Bernhard
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201303300
Subject(s) - rhodium , stereoselectivity , chemistry , catalysis , ligand (biochemistry) , methylene , stereochemistry , medicinal chemistry , combinatorial chemistry , organic chemistry , receptor , biochemistry
Homolargazole derivatives, in which the macrocycle of natural largazole is extended by one methylene group, were prepared by the recently developed rhodium‐catalyzed hydrocarboxylation reaction onto allenes. This strategy gives access to both the (18 S )‐ and (18 R )‐stereoisomers in high stereoselectivity under ligand control.