Premium
Development of a Novel Multifunctional N,P Ligand for Highly Enantioselective Palladium‐Catalyzed Asymmetric Allylic Etherification of Alcohols and Silanols
Author(s) -
Ye Fei,
Zheng ZhanJiang,
Li Li,
Yang KeFang,
Xia ChunGu,
Xu LiWen
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201303233
Subject(s) - allylic rearrangement , palladium , enantioselective synthesis , heteroatom , phosphine , denticity , catalysis , ligand (biochemistry) , phos , chemistry , phosphorus , organic chemistry , medicinal chemistry , ring (chemistry) , receptor , crystal structure , biochemistry
CycloN2P2‐Phos! The use of the multidentate phosphine, CycloN2P2‐Phos (see graphic), which contains four heteroatoms (two nitrogen and two phosphorus atoms), in the palladium‐catalyzed asymmetric allylic etherification (AAE) of alcohols and silanols leads to excellent levels of enantioselectivity (up to 99 % ee ).