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Gold(I)‐Catalyzed Protodecarboxylation of (Hetero)Aromatic Carboxylic Acids
Author(s) -
Dupuy Stéphanie,
Nolan Steven P.
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201303200
Subject(s) - computer science , combinatorial chemistry , simple (philosophy) , chemistry , catalysis , mechanism (biology) , nanotechnology , organic chemistry , materials science , philosophy , epistemology
Golden delivery : A gold(I)–NHC complex catalyses the protodecarboxylation of various (hetero)aromatic acids. This methodology is simple, highly efficient and combines both the advantages of copper and silver methods with applications to completely deactivated substrates. Moreover, intermediates in this reaction have been isolated and fully characterized and provide fundamental insights into the mechanism of protodecarboxylation with gold.