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Visible‐Light‐Induced Radical Cyclization of Trifluoroacetimidoyl Chlorides with Alkynes: Catalytic Synthesis of 2‐Trifluoromethyl Quinolines
Author(s) -
Dong Xichang,
Xu Youwei,
Liu Jing Jing,
Hu Yumin,
Xiao Tiebo,
Zhou Lei
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201303149
Subject(s) - trifluoromethyl , radical , catalysis , chemistry , combinatorial chemistry , computer science , photochemistry , organic chemistry , alkyl
A simple and efficient method for the synthesis of 2‐trifluoromethyl quinolines by means of visible‐light‐induced radical cyclization of trifluoroacetimidoyl chlorides with alkynes has been developed. This protocol allows the generation of imidoyl radicals by activation of C(sp 2 )Cl bonds using a photoredox catalyst under mild and environmentally friendly conditions (see scheme).