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Paradigm Shift from Alkaline (Earth) Metals to Early Transition Metals in Fluoroorganometal Chemistry: Perfluoroalkyl Titanocene(III) Reagents Prepared via Not Titanocene(II) but Titanocene(III) Species
Author(s) -
Fujiu Motohiro,
Hashimoto Ryota,
Nakamura Yuzo,
Aikawa Kohsuke,
Ito Shigekazu,
Mikami Koichi
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201303089
Subject(s) - reagent , chemistry , alkaline earth metal , reactivity (psychology) , transition metal , medicinal chemistry , group 2 organometallic chemistry , inorganic chemistry , organic chemistry , alkali metal , catalysis , molecule , medicine , alternative medicine , pathology
Perfluoroalkyl (R F ) titanocene reagents [Cp 2 Ti III R F ] synthesized via [Cp 2 Ti III Cl] rather than [Cp 2 Ti II ] show new types of perfluoroalkylation reactions. The [Cp 2 Ti III R F ] reagents exhibit a wide variety of reactivity with carbonyl compounds including esters and nitriles, and selectivities far higher than those reported for conventional R F Li and R F MgX reagents.