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The Multicomponent Hantzsch Reaction: Comprehensive Mass Spectrometry Monitoring Using Charge‐Tagged Reagents
Author(s) -
Santos Vanessa G.,
Godoi Marla N.,
Regiani Thaís,
Gama Fernando H. S.,
Coelho Mirela B.,
de Souza Rodrigo O. M. A.,
Eberlin Marcos N.,
Garden Simon J.
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201303065
Subject(s) - reagent , chemistry , mass spectrometry , combinatorial chemistry , charge (physics) , ion , selected reaction monitoring , analytical chemistry (journal) , chromatography , organic chemistry , tandem mass spectrometry , physics , quantum mechanics
A novel strategy for the ESI‐MS monitoring of reaction solutions involving the alternate use of permanently charge‐tagged reagents has been used for comprehensive mass spectrometry monitoring of the multicomponent Hantzsch 1,4‐dihydropyridine reaction. By placing a charge tag on either, or both, of the two key reactants, ion suppression effects for ESI were eliminated or minimized, and comprehensive detection of charge‐tagged intermediates was achieved. The strategy allowed the trapping and characterization of the important intermediates in the mechanism for 1,4‐dihydropyridine formation.