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Copper‐Catalyzed Trifluoromethylation–Cyclization of Enynes: Highly Regioselective Construction of Trifluoromethylated Carbocycles and Heterocycles
Author(s) -
Gao Pin,
Yan XiaoBiao,
Tao Tao,
Yang Fan,
He Ting,
Song XianRong,
Liu XueYuan,
Liang YongMin
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201303025
Subject(s) - trifluoromethylation , regioselectivity , chemistry , catalysis , combinatorial chemistry , organic chemistry , copper , trifluoromethyl , alkyl
Regioselective trifluoromethylation–cyclization : A method for copper‐catalyzed trifluoromethylation–cyclization of simple enynes using the CC triple bond as a nucleophile is reported for the first time (see scheme). The reaction proceeds efficiently in a highly regioselective manner to give various 5‐ or 6 ‐exo‐dig carbocycles and heterocycles in moderate to high yields.