Copper‐Catalyzed Trifluoromethylation–Cyclization of Enynes: Highly Regioselective Construction of Trifluoromethylated Carbocycles and Heterocycles | Zendy

Gao Pin | Zendy; Yan XiaoBiao | Zendy; Tao Tao | Zendy; Yang Fan | Zendy; He Ting | Zendy; Song XianRong | Zendy; Liu XueYuan | Zendy; Liang YongMin | Zendy

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Copper‐Catalyzed Trifluoromethylation–Cyclization of Enynes: Highly Regioselective Construction of Trifluoromethylated Carbocycles and Heterocycles

Author(s) -

Gao Pin,

Yan XiaoBiao,

Tao Tao,

Yang Fan,

He Ting,

Song XianRong,

Liu XueYuan,

Liang YongMin

Publication year - 2013

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201303025

Subject(s) - trifluoromethylation , regioselectivity , chemistry , catalysis , combinatorial chemistry , organic chemistry , copper , trifluoromethyl , alkyl

Regioselective trifluoromethylation–cyclization : A method for copper‐catalyzed trifluoromethylation–cyclization of simple enynes using the CC triple bond as a nucleophile is reported for the first time (see scheme). The reaction proceeds efficiently in a highly regioselective manner to give various 5‐ or 6 ‐exo‐dig carbocycles and heterocycles in moderate to high yields.

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