Copper‐Catalyzed Trifluoromethyl Thiolation—Mild and Efficient Synthesis of Trifluoromethyl Thioethers | Zendy

Rueping Magnus | Zendy; Tolstoluzhsky Nikita | Zendy; Nikolaienko Pavlo | Zendy

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Copper‐Catalyzed Trifluoromethyl Thiolation—Mild and Efficient Synthesis of Trifluoromethyl Thioethers

Author(s) -

Rueping Magnus,

Tolstoluzhsky Nikita,

Nikolaienko Pavlo

Publication year - 2013

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201302692

Subject(s) - trifluoromethyl , thioether , chemistry , copper , catalysis , sulfur , organic chemistry , medicinal chemistry , combinatorial chemistry , alkyl

Mild‐mannered sulfur : A general method for the synthesis of vinyl trifluoromethyl thioethers starting from readily available di‐, tri‐, and tetrasubstituted vinyl iodides was developed (see scheme). A wide variety of substrates were applied in the reaction with CuSCF 3 to give the corresponding products in high yields, within short reaction times, with retention of the initial E / Z isomer ratio. In addition, a copper‐catalyzed trifluoromethyl thioether protocol has been also developed.

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