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Oxime Ligation: A Chemoselective Click‐Type Reaction for Accessing Multifunctional Biomolecular Constructs
Author(s) -
Ulrich Sébastien,
Boturyn Didier,
Marra Alberto,
Renaudet Olivier,
Dumy Pascal
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201302426
Subject(s) - click chemistry , oxime , ligation , context (archaeology) , biocompatible material , nanotechnology , combinatorial chemistry , computer science , conjugate , chemistry , materials science , biomedical engineering , engineering , organic chemistry , biology , microbiology and biotechnology , paleontology , mathematical analysis , mathematics
There is a growing need for biocompatible click reactions in order to prepare multifunctional conjugates, which are valuable molecules for innovative biomedical applications. In this context, we review the recent advances in the implementation of oxime ligation for the synthesis of multivalent or multicomponent systems. The value of these products is emphasized by their use in cell targeting, imaging, synthetic vaccines, and surface modifications.