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Application of H/D Exchange to Hydrogen Bonding in Small Molecules
Author(s) -
Schneider Tanya L.,
Halloran Kevin T.,
Hillner Julie A.,
Conry Rebecca R.,
Linton Brian R.
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201302354
Subject(s) - hydrogen bond , deuterium , hydrogen , small molecule , molecule , hydrogen–deuterium exchange , chemistry , degree (music) , series (stratigraphy) , materials science , physics , organic chemistry , atomic physics , biochemistry , biology , paleontology , acoustics
Do you recognize me? A series of simple amides has been used to demonstrate the application of hydrogen/deuterium exchange in small‐molecule hydrogen bonding. By comparison with similar controls, the degree of protection from H/D exchange can provide insight into the degree of hydrogen bonding (see scheme).