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Rhodium(I)‐Catalyzed Cycloisomerization of Nitrogen‐Tethered Indoles and Alkylidenecyclopropanes: Convenient Access to Polycyclic Indole Derivatives
Author(s) -
Zhang DiHan,
Tang XiangYing,
Wei Yin,
Shi Min
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201302331
Subject(s) - cycloisomerization , rhodium , indole test , catalysis , chemistry , nitrogen , organic chemistry
At the end of its tether : A new synthetic protocol for the preparation of polycyclic indole derivatives has been developed from a rhodium(I)‐catalyzed cycloisomerization of a nitrogen‐tethered indole and alkylidenecyclopropane, affording the corresponding tetrahydro‐β‐carboline derivatives in moderate to good yields (see scheme). Further transformations give a direct and rapid route to tetracyclic compounds through transition‐metal catalysis.