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Electrochemical Synthesis of the Aryl α‐Ketoesters from Acetophenones Mediated by KI
Author(s) -
Zhang Zhenlei,
Su Jihu,
Zha Zhenggen,
Wang Zhiyong
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201302307
Subject(s) - construct (python library) , electrochemistry , combinatorial chemistry , aryl , chemistry , computer science , transformation (genetics) , organic chemistry , programming language , electrode , biochemistry , alkyl , gene
Two CO bonds formed in one step : The oxidative coupling reaction of acetophenones with alcohol was developed by a dioxygen activation to afford α‐ketoesters under electrochemical conditions. This novel transformation not only provides a simple and efficient approach to synthetize α‐ketoester derivatives, but also invents a new strategy to construct a CO bond by virtue of an anode oxidation (see scheme).