Premium
Synthesis of C ‐Disaccharides through a One‐Pot Alkynol Cycloisomerization‐Reductive Deoxygenation
Author(s) -
Narute Sachin B.,
Rout Jeetendra Kumar,
Ramana Chepuri V.
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201302252
Subject(s) - cycloisomerization , deoxygenation , furan , pyran , computer science , chemistry , disaccharide , combinatorial chemistry , stereochemistry , organic chemistry , catalysis
A sweet disposition : Simple protocols for the synthesis of (1→1)‐ and (1→6)‐linked C ‐disaccharides have been developed (see scheme). A one‐pot Au‐catalyzed alkynol cycloisomerization followed by BF 3 ⋅ Et 2 O, Et 3 SiH reduction has been established as the key reaction for C ‐disaccharide synthesis including all possible pyran–pyran, furan–furan, and pyran–furan combinations.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom