Mirror‐Image Organometallic Osmium Arene Iminopyridine Halido Complexes Exhibit Similar Potent Anticancer Activity | Zendy

Fu Ying | Zendy; Soni Rina | Zendy; Romero María J. | Zendy; Pizarro Ana M. | Zendy; Salassa Luca | Zendy; Clarkson Guy J. | Zendy; Hearn Jessica M. | Zendy; Habtemariam Abraha | Zendy; Wills Martin | Zendy; Sadler Peter J. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Mirror‐Image Organometallic Osmium Arene Iminopyridine Halido Complexes Exhibit Similar Potent Anticancer Activity

Author(s) -

Fu Ying,

Soni Rina,

Romero María J.,

Pizarro Ana M.,

Salassa Luca,

Clarkson Guy J.,

Hearn Jessica M.,

Habtemariam Abraha,

Wills Martin,

Sadler Peter J.

Publication year - 2013

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201302183

Subject(s) - chemistry , osmium , cisplatin , stereochemistry , medicinal chemistry , catalysis , combinatorial chemistry , biochemistry , biology , chemotherapy , ruthenium , genetics

Four chiral Os II arene anticancer complexes have been isolated by fractional crystallization. The two iodido complexes, ( S Os , S C )‐[Os(η 6 ‐ p ‐cym)(ImpyMe)I]PF 6 (complex 2 , ( S )‐ImpyMe: N ‐(2‐pyridylmethylene)‐( S )‐1‐phenylethylamine) and ( R Os , R C )‐[Os(η 6 ‐ p ‐cym)(ImpyMe)I]PF 6 (complex 4 , ( R )‐ImpyMe: N ‐(2‐pyridylmethylene)‐( R )‐1‐phenylethylamine), showed higher anticancer activity (lower IC 50 values) towards A2780 human ovarian cancer cells than cisplatin and were more active than the two chlorido derivatives, ( S Os , S C ) ‐ [Os(η 6 ‐ p ‐cym)(ImpyMe)Cl]PF 6 , 1 , and ( R Os , R C )‐[Os(η 6 ‐ p ‐cym)(ImpyMe)Cl]PF 6 , 3 . The two iodido complexes were evaluated in the National Cancer Institute 60‐cell‐line screen, by using the COMPARE algorithm. This showed that the two potent iodido complexes, 2 (NSC: D‐758116/1) and 4 (NSC: D‐758118/1), share surprisingly similar cancer cell selectivity patterns with the anti‐microtubule drug, vinblastine sulfate. However, no direct effect on tubulin polymerization was found for 2 and 4 , an observation that appears to indicate a novel mechanism of action. In addition, complexes 2 and 4 demonstrated potential as transfer‐hydrogenation catalysts for imine reduction.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research