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Palladium‐Catalyzed Carbonylative Synthesis of Quinazolinones from 2‐Aminobenzamide and Aryl Bromides
Author(s) -
Wu XiaoFeng,
He Lin,
Neumann Helfried,
Beller Matthias
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201302182
Subject(s) - palladium , aryl , catalysis , carbonylation , combinatorial chemistry , chemistry , organic chemistry , carbon monoxide , alkyl
C from CO! A straightforward procedure for the carbonylative synthesis of quinazolinones from readily available 2‐aminobenzamide and aryl bromides has been developed. In the presence of a palladium catalyst, various quinazolinones were produced in moderate to excellent yields. Remarkably, no chromatography was needed for purification (see scheme).