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CS Coupling Using a Mixed‐Ligand Pd Catalyst: A Highly Effective Strategy for Synthesizing Arylthio‐Substituted Heterocycles
Author(s) -
Cong Mei,
Fan Yuting,
Raimundo JeanManuel,
Xia Yi,
Liu Yang,
Quéléver Gilles,
Qu Fanqi,
Peng Ling
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201302174
Subject(s) - xantphos , catalysis , palladium , ligand (biochemistry) , combinatorial chemistry , halide , chemistry , coupling (piping) , organic chemistry , materials science , biochemistry , receptor , metallurgy
CS coupling : A variety of arylthio‐substituted heterocycles can be prepared through CS coupling of the corresponding halide‐substituted heterocycles by using a mixed‐ligand palladium catalyst, [Pd 2 (dba) 3 ]/ Xantphos/CyPF‐ t Bu (see scheme; dba=dibenzylideneacetone). This catalytic system is extremely powerful and efficient, allowing even CCl bond activation.