Enhanced Efficacy and Broadening of Antibacterial Action of Drugs via the Use of Capped Mesoporous Nanoparticles | Zendy

Mas Núria | Zendy; Galiana Irene | Zendy; Mondragón Laura | Zendy; Aznar Elena | Zendy; Climent Estela | Zendy; Cabedo Nuria | Zendy; Sancenón Félix | Zendy; Murguía José Ramón | Zendy; MartínezMáñez Ramón | Zendy; Marcos María D. | Zendy; Amorós Pedro | Zendy

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Enhanced Efficacy and Broadening of Antibacterial Action of Drugs via the Use of Capped Mesoporous Nanoparticles

Author(s) -

Mas Núria,

Galiana Irene,

Mondragón Laura,

Aznar Elena,

Climent Estela,

Cabedo Nuria,

Sancenón Félix,

Murguía José Ramón,

MartínezMáñez Ramón,

Marcos María D.,

Amorós Pedro

Publication year - 2013

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201302170

Subject(s) - nanodevice , nanoparticle , antimicrobial , nanotechnology , mesoporous material , action (physics) , computer science , chemistry , combinatorial chemistry , materials science , physics , biochemistry , organic chemistry , quantum mechanics , catalysis

Bug busters : A novel nanodevice consisting of mesoporous nanoparticles loaded with vancomycin and capped with ε‐poly‐ L ‐lysine (ε‐PL) was prepared and its interaction with different Gram‐negative bacteria studied (see figure). A remarkable improvement in the efficacy of the antimicrobial drug ε‐PL and a broadening of the antimicrobial spectrum of vancomycin is demonstrated.

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