Premium
Enhanced Efficacy and Broadening of Antibacterial Action of Drugs via the Use of Capped Mesoporous Nanoparticles
Author(s) -
Mas Núria,
Galiana Irene,
Mondragón Laura,
Aznar Elena,
Climent Estela,
Cabedo Nuria,
Sancenón Félix,
Murguía José Ramón,
MartínezMáñez Ramón,
Marcos María D.,
Amorós Pedro
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201302170
Subject(s) - nanodevice , nanoparticle , antimicrobial , nanotechnology , mesoporous material , action (physics) , computer science , chemistry , combinatorial chemistry , materials science , physics , biochemistry , organic chemistry , quantum mechanics , catalysis
Bug busters : A novel nanodevice consisting of mesoporous nanoparticles loaded with vancomycin and capped with ε‐poly‐ L ‐lysine (ε‐PL) was prepared and its interaction with different Gram‐negative bacteria studied (see figure). A remarkable improvement in the efficacy of the antimicrobial drug ε‐PL and a broadening of the antimicrobial spectrum of vancomycin is demonstrated.