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Copper‐Catalyzed Oxidative Benzylarylation of Acrylamides by Benzylic CH Bond Functionalization for the Synthesis of Oxindoles
Author(s) -
Zhou ShiLiu,
Guo LiNa,
Wang Hua,
Duan XinHua
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201302139
Subject(s) - catalysis , chemistry , oxidative phosphorylation , tandem , combinatorial chemistry , organic chemistry , computer science , materials science , biochemistry , composite material
Radically changing benzyls : An efficient method for the benzylarylation of activated alkenes has been developed through a copper‐catalyzed tandem radical addition/cyclization strategy (see scheme). This oxidative coupling between acrylamides and benzylic hydrocarbons provides access to diverse alkyl‐substituted oxindoles in good to excellent yields. A variety of functional groups were tolerated in this transformation (TBPB =tert ‐butylperoxy benzoate).