Copper‐Catalyzed Oxidative Benzylarylation of Acrylamides by Benzylic CH Bond Functionalization for the Synthesis of Oxindoles | Zendy

Zhou ShiLiu | Zendy; Guo LiNa | Zendy; Wang Hua | Zendy; Duan XinHua | Zendy

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Copper‐Catalyzed Oxidative Benzylarylation of Acrylamides by Benzylic CH Bond Functionalization for the Synthesis of Oxindoles

Author(s) -

Zhou ShiLiu,

Guo LiNa,

Wang Hua,

Duan XinHua

Publication year - 2013

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201302139

Subject(s) - catalysis , chemistry , oxidative phosphorylation , tandem , combinatorial chemistry , organic chemistry , computer science , materials science , biochemistry , composite material

Radically changing benzyls : An efficient method for the benzylarylation of activated alkenes has been developed through a copper‐catalyzed tandem radical addition/cyclization strategy (see scheme). This oxidative coupling between acrylamides and benzylic hydrocarbons provides access to diverse alkyl‐substituted oxindoles in good to excellent yields. A variety of functional groups were tolerated in this transformation (TBPB =tert ‐butylperoxy benzoate).

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