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A Fluorescent Guanosine Dinucleoside as a Selective Switch‐On Sensor for c‐myc G‐Quadruplex DNA with Potent Anticancer Activities
Author(s) -
Kumar Y. Pavan,
Bhowmik Sudipta,
Das Rabindra Nath,
Bessi Irene,
Paladhi Sushovan,
Ghosh Rita,
Schwalbe Harald,
Dash Jyotirmayee
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201302107
Subject(s) - guanosine , g quadruplex , dna , fluorescence , chemistry , deoxyguanosine , nucleoside , duplex (building) , nucleic acid , biophysics , microbiology and biotechnology , combinatorial chemistry , cancer research , biochemistry , biology , physics , quantum mechanics
Like likes like! A novel fluorescent C 2 ‐symmetric guanosine‐based dinucleoside has been engineered by chemical ligation of two guanosine units with a biocompatible dansyl tag. The nucleoside exhibits high selectivity for c‐myc G‐quadruplex DNA through fluorescence enhancement over duplex DNA and other promoter G‐quadruplexes (see scheme). It stains the nucleus preferentially, arrests the cell cycle at the G2/M phase, inhibits cell growth, and induces apoptosis in A375 cancer cells.