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Direct Transformation of Methyl Imines to α‐Iminonitriles under Mild and Transition‐Metal‐Free Conditions
Author(s) -
Chen Feng,
Huang Xiaoqiang,
Cui Yuxin,
Jiao Ning
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201301933
Subject(s) - transformation (genetics) , transition metal , transition (genetics) , chemistry , organic chemistry , catalysis , biochemistry , gene
A novel transformation of methyl imines into α‐iminonitriles under mild and transition‐metal‐free conditions is described. Three C sp 3H bonds are cleaved in a radical pathway at room temperature under air. Simple bromide salts are employed to assist this radical process (see scheme; FG=functional group, PIDA = iodobenzene diacetate, TMS = trimethylsilyl).
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