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Kinetic Resolution and Stereoselective Synthesis of 3‐Substituted Aspartic Acids by Using Engineered Methylaspartate Ammonia Lyases
Author(s) -
Raj Hans,
Szymanski Wiktor,
de Villiers Jandré,
Puthan Veetil Vinod,
Quax Wim J.,
Shimamoto Keiko,
Janssen Dick B.,
Feringa Ben L.,
Poelarends Gerrit J.
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201301832
Subject(s) - diastereomer , aspartic acid , chemistry , combinatorial chemistry , ammonia , enantiomer , stereoselectivity , kinetic resolution , enantiomeric excess , resolution (logic) , computer science , biochemical engineering , organic chemistry , amino acid , enantioselective synthesis , catalysis , biochemistry , programming language , engineering
Enzymatic amino acid synthesis : Kinetic resolution and asymmetric synthesis of various valuable 3‐substituted aspartic acids, which were obtained in fair to good yields with diastereomeric ratio values of up to >98:2 and enantiomeric excess values of up to >99 %, by using engineered methylaspartate ammonia lyases (see figure) are described. These biocatalytic methodologies for the selective preparation of aspartic acid derivatives appear to be attractive alternatives for existing chemical methods.