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Cyclometalated Iridium(III) Complexes with Deoxyribose Substituents
Author(s) -
Maity Ayan,
Choi JungSuk,
Teets Thomas S.,
Deligonul Nihal,
Berdis Anthony J.,
Gray Thomas G.
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201301776
Subject(s) - deoxyribose , nucleobase , iridium , nucleoside , chemistry , nucleoside analogue , stereochemistry , nucleic acid , biochemistry , dna , catalysis
Fundamental study of enzymatic nucleoside transport suffers for lack of optical probes that can be tracked noninvasively. Nucleoside transporters are integral membrane glycoproteins that mediate the salvage of nucleosides and their passage across cell membranes. The substrate recognition site is the deoxyribose sugar, often with little distinction among nucleobases. Reported here are nucleoside analogues in which emissive, cyclometalated iridium(III) complexes are “clicked” to C‐1 of deoxyribose in place of canonical nucleobases. The resulting complexes show visible luminescence at room temperature and 77 K with microsecond‐length triplet lifetimes. A representative complex is crystallographically characterized. Transport and luminescence are demonstrated in cultured human carcinoma (KB3‐1) cells.