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A Cascade Coupling Strategy for One‐Pot Total Synthesis of β‐Carboline and Isoquinoline‐Containing Natural Products and Derivatives
Author(s) -
Zhu YanPing,
Liu MeiCai,
Cai Qun,
Jia FengCheng,
Wu AnXin
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201301734
Subject(s) - isoquinoline , cascade , computer science , coupling (piping) , natural product , total synthesis , combinatorial chemistry , natural (archaeology) , chemistry , organic chemistry , engineering , biology , chromatography , mechanical engineering , paleontology
Multi‐birds with one stone : A cascade coupling strategy was developed for the synthesis of β‐carbolines. The method can direct the synthesis of β‐carboline and isoquinoline‐containing natural products with high yields. Moreover, this protocol can also be further applied towards the total synthesis of natural products fascaplysin and papaverin (see scheme).