Premium
Fast Synthesis of Complex Enantiopure Heterocyclic Scaffolds by a Tandem Sequence of Simple Transformations on α‐Hydroxyaldehydes
Author(s) -
Cannillo Alexandre,
Norsikian Stéphanie,
Retailleau Pascal,
Dau MarieElise Tran Huu,
Iorga Bogdan I.,
Beau JeanMarie
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201301712
Subject(s) - enantiopure drug , tandem , sequence (biology) , simple (philosophy) , scheme (mathematics) , combinatorial chemistry , chemistry , computer science , mathematics , organic chemistry , engineering , catalysis , biochemistry , mathematical analysis , philosophy , epistemology , enantioselective synthesis , aerospace engineering
Two tandems are faster than one! Properly sequenced reactions initiated by the Petasis aminoalcohol synthesis from boronic acids, diallylamine, and α‐hydroxyaldehydes, including free aldoses, leads to rapid construction of complex enantiopure structures (see scheme).