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Custom‐Fit Ruthenium(II) Metallopeptides: A New Twist to DNA Binding With Coordination Compounds
Author(s) -
Gamba Ilaria,
Salvadó Iria,
Rama Gustavo,
Bertazzon Miriam,
Sánchez Mateo I.,
SánchezPedregal Víctor M.,
MartínezCostas José,
Brissos Rosa F.,
Gamez Patrick,
Mascareñas José L.,
Vázquez López Miguel,
Vázquez M. Eugenio
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201301629
Subject(s) - ruthenium , dna , combinatorial chemistry , minor groove , chemistry , internalization , derivative (finance) , fluorescence , stereochemistry , biophysics , biochemistry , cell , biology , physics , quantum mechanics , financial economics , economics , catalysis
A new bipyridine building block has been used for the solid‐phase synthesis of dinuclear DNA‐binding ruthenium(II) metallopeptides. Detailed spectroscopic studies suggest that these compounds bind to the DNA by insertion into the DNA minor groove. Moreover, the potential of the solid‐phase peptide synthesis approach is demonstrated by the straightforward synthesis of an octaarginine derivative that shows effective cellular internalization and cytotoxicity linked with strong DNA interaction, as evidenced by steady‐state fluorescence spectroscopy and AFM studies.