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In Situ Generation of PhI + CF 3 and Transition‐Metal‐Free Oxidative sp 2 CH Trifluoromethylation
Author(s) -
Xu Cong,
Liu Jingxin,
Ming Wenbo,
Liu Yingjie,
Liu Jun,
Wang Mang,
Liu Qun
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201301585
Subject(s) - electrophile , reagent , chemistry , transition metal , in situ , computer science , library science , combinatorial chemistry , organic chemistry , catalysis
These things are sent to tri us : The introduction of CF 3 units into organic molecules is important and requires the development of convenient trifluoromethylating reagents. Here, PhI + CF 3 , an acyclic electrophilic “CF 3 + ” species, is described, including its in situ generation from TMSCF 3 , PhI(OAc) 2 , and KF and its direct applications in sp 2 CH trifluoromethylations under mild transition‐metal‐free conditions (see scheme).