In Situ Generation of PhI + CF 3  and Transition‐Metal‐Free Oxidative sp 2  CH Trifluoromethylation | Zendy

Xu Cong | Zendy; Liu Jingxin | Zendy; Ming Wenbo | Zendy; Liu Yingjie | Zendy; Liu Jun | Zendy; Wang Mang | Zendy; Liu Qun | Zendy

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In Situ Generation of PhI + CF 3 and Transition‐Metal‐Free Oxidative sp 2 CH Trifluoromethylation

Author(s) -

Xu Cong,

Liu Jingxin,

Ming Wenbo,

Liu Yingjie,

Liu Jun,

Wang Mang,

Liu Qun

Publication year - 2013

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201301585

Subject(s) - electrophile , reagent , chemistry , transition metal , in situ , computer science , library science , combinatorial chemistry , organic chemistry , catalysis

These things are sent to tri us : The introduction of CF 3 units into organic molecules is important and requires the development of convenient trifluoromethylating reagents. Here, PhI + CF 3 , an acyclic electrophilic “CF 3 + ” species, is described, including its in situ generation from TMSCF 3 , PhI(OAc) 2 , and KF and its direct applications in sp 2 CH trifluoromethylations under mild transition‐metal‐free conditions (see scheme).

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