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Comparison of Lipoic and Asparagusic Acid for Surface‐Initiated Disulfide‐Exchange Polymerization
Author(s) -
Carmine Alessio,
Domoto Yuya,
Sakai Naomi,
Matile Stefan
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201301567
Subject(s) - lipoic acid , disulfide bond , polymerization , substrate (aquarium) , ideal (ethics) , chemistry , polymer chemistry , combinatorial chemistry , nanotechnology , materials science , organic chemistry , biochemistry , polymer , biology , antioxidant , ecology , philosophy , epistemology
Bring it on : Organic chemistry on surfaces and in solution is not the same; this study offers a perfect example that small changes (from 27 to 35°; see graphic) can result in big consequences. Strained cyclic disulfides from asparagusic, but not lipoic acid, are ideal for growing functional architectures directly on surfaces; for the substrate‐initiated synthesis of cell‐penetrating poly(disulfide)s in solution, exactly the contrary is true.