Premium
Probing the Relevance of NHC Ligand Conformations in the Ru‐Catalysed Ring‐Closing Metathesis Reaction
Author(s) -
Perfetto Alessandra,
Costabile Chiara,
Longo Pasquale,
Bertolasi Valerio,
Grisi Fabia
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201301540
Subject(s) - ring closing metathesis , metathesis , salt metathesis reaction , chemistry , ruthenium , ligand (biochemistry) , catalysis , aryl , combinatorial chemistry , stereochemistry , substituent , computer science , organic chemistry , polymerization , biochemistry , alkyl , receptor , polymer
Cat power : Judicious backbone substitution of N‐heterocyclic carbenes (NHCs) leads to stable Ru metathesis catalysts with frozen NHC conformations. This finding not only permits the isolation of complexes that are among the most active catalysts in the ring‐closing metathesis of hindered olefins (see graphic; Ts= p ‐toluenesulfonyl), but also provides fundamental mechanistic insights on the role of N ‐aryl substituent conformations on catalyst activity.