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A Hybrid Ring‐Opening Metathesis Polymerization Catalyst Based on an Engineered Variant of the β‐Barrel Protein FhuA
Author(s) -
Philippart Freddi,
Arlt Marcus,
Gotzen Steve,
Tenne StefanieJoana,
Bocola Marco,
Chen HsuiHui,
Zhu Leilei,
Schwaneberg Ulrich,
Okuda Jun
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201301515
Subject(s) - barrel (horology) , polymerization , metathesis , catalysis , chemistry , derivative (finance) , cysteine , acyclic diene metathesis , polymer chemistry , aqueous solution , combinatorial chemistry , organic chemistry , materials science , polymer , enzyme , financial economics , economics , composite material
A β‐barrel protein hybrid catalyst was prepared by covalently anchoring a Grubbs–Hoveyda type olefin metathesis catalyst at a single accessible cysteine amino acid in the barrel interior of a variant of β‐barrel transmembrane protein ferric hydroxamate uptake protein component A (FhuA). Activity of this hybrid catalyst type was demonstrated by ring‐opening metathesis polymerization of a 7‐oxanorbornene derivative in aqueous solution.
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