Premium
Cp*Co III ‐Catalyzed C2‐Selective Addition of Indoles to Imines
Author(s) -
Yoshino Tatsuhiko,
Ikemoto Hideya,
Matsunaga Shigeki,
Kanai Motomu
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201301505
Subject(s) - catalysis , reactivity (psychology) , regioselectivity , frustrated lewis pair , chemistry , friedel–crafts reaction , combinatorial chemistry , substrate (aquarium) , lewis acids and bases , computer science , organic chemistry , medicine , oceanography , alternative medicine , pathology , geology
Overriding innate reactivity : The utility of a Co III catalyst to promote the C2‐selective addition of indoles to imines was demonstrated. The Co III catalyst completely changed the regioselectivity in comparison with simple Lewis acid catalyzed Friedel–Crafts C3‐selective addition. High turnover number (TON) of the catalyst, up to 1.8×10 2 (with s / c =200; see scheme; s/c is the substrate/catalyst ratio), was achieved.