Premium
Enantioselective Aza‐Michael Addition of Imides by Using an Integrated Strategy Involving the Synthesis of a Family of Multifunctional Catalysts, Usage of Multiple Catalysis, and Rational Design of Experiment
Author(s) -
Silvi Mattia,
Renzi Polyssena,
Rosato Deborah,
Margarita Cristiana,
Vecchioni Alessio,
Bordacchini Ivan,
Morra Diego,
Nicolosi Alessandro,
Cari Riccardo,
Sciubba Fabio,
Scarpino Schietroma Daniele M.,
Bella Marco
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201301493
Subject(s) - enantioselective synthesis , catalysis , michael reaction , rational design , organic chemistry , combinatorial chemistry , chemistry , nanotechnology , materials science
A challenging asymmetric reaction (aza‐Michael addition of imides to enones) has been optimized through an integrated approach involving the synthesis of a family of organocatalysts, multiple catalysis (usage of additives), and finally with rational exploration of the chemical space by the application of the experiment design.