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Salimabromide: Unexpected Chemistry from the Obligate Marine Myxobacterium Enhygromyxa salina
Author(s) -
Felder Stephan,
Dreisigacker Sandra,
Kehraus Stefan,
Neu Edith,
Bierbaum Gabriele,
Wright Patrick R.,
Menche Dirk,
Schäberle Till F.,
König Gabriele M.
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201301379
Subject(s) - myxobacteria , stereochemistry , chemistry , natural product , ring (chemistry) , moiety , carbon skeleton , absolute configuration , residue (chemistry) , organic chemistry , biology , bacteria , paleontology
Marine myxobacteria ( Enhygromyxa , Plesiocystis , Pseudoenhygromyxa , Haliangium ) are phylogenetically distant from their terrestrial counterparts. Salimabromide is the first natural product from the Plesiocystis / Enhygromyxa clade of obligatory marine myxobacteria. Salimabromide has a new tetracyclic carbon skeleton, comprising a brominated benzene ring, a furano lactone residue, and a cyclohexane ring, bridged by a seven‐membered cyclic moiety. The absolute configuration was deduced from experimental and calculated CD data. Salimabromide revealed antibiotic activity towards Arthrobacter cristallopoietes .