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Rh‐Catalyzed Direct Enantioselective Alkynylation of α‐Ketiminoesters
Author(s) -
Morisaki Kazuhiro,
Sawa Masanao,
Nomaguchi Junya,
Morimoto Hiroyuki,
Takeuchi Yosuke,
Mashima Kazushi,
Ohshima Takashi
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201301237
Subject(s) - enantioselective synthesis , alkynylation , catalysis , chemistry , combinatorial chemistry , organic chemistry
A green way to amino acids : α‐Tetrasubstituted α‐amino acid derivatives are formed in high yield and enantioselectivity by using a Rh‐catalyzed enantioselective alkynylation of α‐ketiminoesters. This reaction, which involves a proton transfer and can be conducted at room temperature, has high substrate scope (see scheme; Cbz=benzyloxycarbonyl, Fmoc=9‐fluorenylmethyloxycarbonyl).
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