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Silver Ion Promoted, Pd II ‐Catalyzed Arylation of Arenes with a Free Amine as Directing Group in Aqueous Medium
Author(s) -
Liang Zunjun,
Yao Jinzhong,
Wang Kai,
Li Haoran,
Zhang Yuhong
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201301229
Subject(s) - chemoselectivity , amine gas treating , chemistry , palladium , aryl , catalysis , aqueous solution , aqueous medium , reactivity (psychology) , yield (engineering) , organic chemistry , medicinal chemistry , combinatorial chemistry , polymer chemistry , alkyl , materials science , alternative medicine , pathology , metallurgy , medicine
Abstract Palladium(II)‐catalyzed arylation of arenes with aryl boronic acids and a free amine as directing group in aqueous medium has been developed. High reactivity and chemoselectivity for the formation of carbon–carbon bonds were achieved by the use of soluble silver salts. The addition of water is crucial to improve the arylation yield.